Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs.
Identifieur interne : 000402 ( Main/Exploration ); précédent : 000401; suivant : 000403Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs.
Auteurs : Yumi Kondo [Japon] ; Gen Kinoshita [Japon] ; Marlene Drag [États-Unis] ; Theodore S. Chester [États-Unis] ; Diane Larsen [États-Unis]Source :
- Veterinary parasitology ; 2014.
English descriptors
- KwdEn :
- Acaricides (therapeutic use), Animals, Dog Diseases (drug therapy), Dog Diseases (prevention & control), Dogs, Female, Isoxazoles (administration & dosage), Ixodidae, Male, Naphthalenes (administration & dosage), Random Allocation, Tick Infestations (drug therapy), Tick Infestations (prevention & control), Tick Infestations (veterinary), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Isoxazoles, Naphthalenes.
- chemical , therapeutic use : Acaricides.
- drug therapy : Dog Diseases, Tick Infestations.
- prevention & control : Dog Diseases, Tick Infestations.
- veterinary : Tick Infestations.
- Animals, Dogs, Female, Ixodidae, Male, Random Allocation, Treatment Outcome.
Abstract
A controlled study to assess the acaricidal efficacy of afoxolaner in dogs after a single oral administration was conducted against Haemaphysalis longicornis ticks. The study was characterized by a negative controlled randomized block design and included sixteen beagle dogs of both sexes. Starting two days before treatment, each dog was infested weekly with 50 ticks over 4 weeks. The number of live ticks was determined 48 h after treatment and then 48 h after each infestation. The mean dose of afoxolaner received by dogs was 3.0mg/kg (range: 2.5-3.1mg/kg). Afoxolaner rapidly eliminated pre-existing tick infestations (100% ticks killed within 48 h of treatment) and controlled weekly re-infestations (91.9% prophylactic efficacy at Day 30).
DOI: 10.1016/j.vetpar.2014.02.019
PubMed: 24629429
Affiliations:
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Le document en format XML
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The study was characterized by a negative controlled randomized block design and included sixteen beagle dogs of both sexes. Starting two days before treatment, each dog was infested weekly with 50 ticks over 4 weeks. The number of live ticks was determined 48 h after treatment and then 48 h after each infestation. The mean dose of afoxolaner received by dogs was 3.0mg/kg (range: 2.5-3.1mg/kg). Afoxolaner rapidly eliminated pre-existing tick infestations (100% ticks killed within 48 h of treatment) and controlled weekly re-infestations (91.9% prophylactic efficacy at Day 30).</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Kondo, Yumi" sort="Kondo, Yumi" uniqKey="Kondo Y" first="Yumi" last="Kondo">Yumi Kondo</name></noRegion><name sortKey="Kinoshita, Gen" sort="Kinoshita, Gen" uniqKey="Kinoshita G" first="Gen" last="Kinoshita">Gen Kinoshita</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Drag, Marlene" sort="Drag, Marlene" uniqKey="Drag M" first="Marlene" last="Drag">Marlene Drag</name></region><name sortKey="Chester, Theodore S" sort="Chester, Theodore S" uniqKey="Chester T" first="Theodore S" last="Chester">Theodore S. Chester</name><name sortKey="Larsen, Diane" sort="Larsen, Diane" uniqKey="Larsen D" first="Diane" last="Larsen">Diane Larsen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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